Issue 11, 2022

Ultra-small bimetallic phosphides for dual-modal MRI imaging guided photothermal ablation of tumors

Abstract

Metal phosphides have been proved to be potential theranostic agents of tumors. However, the limitations of single-modal imaging or the treatment effect of such materials need to be further improved. Here, we successfully prepared polyvinylpyrrolidone-modified bimetallic nickel cobalt phosphide (NiCoP/PVP) nanoparticles as a theranostic agent of tumors. Owing to the different types of magnetic properties of Ni and Co components, T1- and T2-weighted magnetic resonance imaging (MRI) could be simultaneously achieved to compensate the low accuracy brought about by single-modal MRI. In addition, NiCoP/PVP possesses excellent photothermal properties owing to its obvious absorption in the near-infrared (NIR) region, which endows NiCoP/PVP with high photothermal conversion efficiency (PCE) to serve as a photothermal agent for tumor ablation. Therefore, NiCoP/PVP is a promising theranostic agent for accurate diagnosis and effective treatment of tumors.

Graphical abstract: Ultra-small bimetallic phosphides for dual-modal MRI imaging guided photothermal ablation of tumors

Supplementary files

Article information

Article type
Paper
Submitted
18 Nov 2021
Accepted
24 Jan 2022
First published
15 Feb 2022

Dalton Trans., 2022,51, 4423-4428

Ultra-small bimetallic phosphides for dual-modal MRI imaging guided photothermal ablation of tumors

Y. Lu, P. Zhang, L. Lin, X. Gao, Y. Zhou, J. Feng and H. Zhang, Dalton Trans., 2022, 51, 4423 DOI: 10.1039/D1DT03898B

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