Tethered photocatalyst-directed palladium-catalysed C–H allenylation of N-aryl tetrahydroisoquinolines

Abstract

Harnessing radical intermediates in regioselective reactions presents a substantial challenge. Here, we report a novel control strategy through engineering covalently tethered transition metal–photocatalysts that conjoin Pd–phosphine and Ru/Ir photoredox units. This strategy allows us to override the innate regioselectivity of the Pd-catalysed C–H allenylation of N-aryl tetrahydroisoquinolines.