Palladium-catalyzed divergent cycloisomerization of 1,6-enynes controlled by functional groups for the synthesis of pyrroles, cyclopentenes, and tetrahydropyridines

Abstract

With control by functional groups, catalytic divergent cycloisomerization of 1,6-enynes is achieved for the synthesis of pyrrole, cyclopentene, and tetra-hydropyridine derivatives using the combination of a Pd(0) catalyst with glucose. Detailed DFT calculations have provided evidence for the different pathways of selective cyclization/isomerization.