Synthesis of strained 1,2-diazetidines via [3 + 1] cycloaddition of C,N-cyclic azomethine imines with isocyanides and synthetic derivation

Abstract

Strained diazetidines are assembled simply by 1,3-dipolar cycloaddition of isocyanides and C,N-cyclic azomethine imines. This catalyst-free protocol proceeds smoothly in very mild conditions, and a wide range of isocyanides and C,N-cyclic azomethine imines are applicable to the reaction. The diazetidines obtained are versatile intermediates for diversified transformations.