Issue 5, 2021

Mesoporous silica-coated gold nanorods loaded with tetrazolyl phthalocyanine as NIR light-activated nano-switches for synergistic photothermal and photodynamic inactivation of antibiotic-resistant Escherichia coli

Abstract

A light-controlled nano-switch was prepared by assembling mesoporous silica-coated gold nanorods with bis-(1-(4-hydroxyphenyl)-5-mercapto-tetrazolyl) silicon(IV) phthalocyanines, which exhibited excellent triple functions with controlled release of phthalocyanines and generation of reactive oxygen species (ROS) as well as temperature enhancement under laser irradiation. The nano-switch achieved an effective antimicrobial activity against a variety of antibiotic-resistant Escherichia coli strains through synergistic photodynamic therapy and photothermal therapy by damaging the genomic DNA and enzyme activity of bacteria.

Graphical abstract: Mesoporous silica-coated gold nanorods loaded with tetrazolyl phthalocyanine as NIR light-activated nano-switches for synergistic photothermal and photodynamic inactivation of antibiotic-resistant Escherichia coli

Supplementary files

Article information

Article type
Paper
Submitted
09 Oct 2020
Accepted
14 Jan 2021
First published
16 Jan 2021
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2021,2, 1695-1705

Mesoporous silica-coated gold nanorods loaded with tetrazolyl phthalocyanine as NIR light-activated nano-switches for synergistic photothermal and photodynamic inactivation of antibiotic-resistant Escherichia coli

Q. Ye, S. Xiao, T. Lin, Y. Jiang, Y. Peng and Y. Huang, Mater. Adv., 2021, 2, 1695 DOI: 10.1039/D0MA00782J

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