Issue 4, 2022

A β-hairpin peptide with pH-controlled affinity for tumor cells

Abstract

Considering that the pH in the tumor microenvironment is dysregulated, we designed a β-hairpin peptide (SSRFEWEFESSDPRGDPSSRFEWEFESS). The configuration of the peptide switched from a flexible linear to a rigid loop structure under weakly acidic conditions. The peptide internalized by tumor cells increased significantly under weakly acidic conditions.

Graphical abstract: A β-hairpin peptide with pH-controlled affinity for tumor cells

Supplementary files

Article information

Article type
Communication
Submitted
04 Nov 2021
Accepted
18 Nov 2021
First published
18 Nov 2021

Chem. Commun., 2022,58, 505-508

A β-hairpin peptide with pH-controlled affinity for tumor cells

S. Nishimura, K. Nishida and M. Tanaka, Chem. Commun., 2022, 58, 505 DOI: 10.1039/D1CC06218B

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