Tertiary cyclopropyl carbagermatranes: synthesis and cross-coupling†
The construction of the cyclopropyl quaternary carbon center can afford a series of 1,1-olefin bioisosteres. Here, we report tertiary cyclopropyl carbagermatranes, which can be easily obtained by the zinc-mediated decarboxylation of NHP esters. In addition, they exhibit efficient reactivity in the palladium-catalyzed cross-coupling reaction and orthogonal reactivity with boron reagents, therefore acting as robust nucleophiles for the synthesis of tertiary cyclopropane and efficient intermediates for the formation of quaternary centers.
- This article is part of the themed collections: 10th Anniversary of the Youth Innovation Promotion Association of the Chinese Academy of Science and Chemical Communications HOT articles