Glycosylation plays important roles in SARS-CoV-2 infection. We describe here a facile chemoenzymatic synthesis of core-fucosylated N-glycopeptides derived from the SARS-CoV-2 Spike protein and their binding with glycan-dependent neutralizing antibody S309 and human lectin CLEC4G. The synthetic glycopeptides provide tools for further functional characterization of viral glycosylation.
G. Zong, C. Li, S. K. Prabhu, R. Zhang, X. Zhang and L. Wang, Chem. Commun., 2021, 57, 6804 DOI: 10.1039/D1CC02790E
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