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Nongenetic control of receptor signaling dynamics using a DNA-based optochemical tool

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Abstract

Optochemical tools that can modulate the activity of the target protein provide an opportunity for studying and regulating the related biological processes. Here we present a DNA-based nongenetic optochemical tool that can control the dynamics of growth factor signaling. This photo-caged mimicry of growth factor can be a promising tool for elucidating a linkage between the dynamics of signaling and the resulting biological outcomes, as well as for manipulating cellular functions and the fate of living cells.

Graphical abstract: Nongenetic control of receptor signaling dynamics using a DNA-based optochemical tool

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Article information


Submitted
13 Apr 2021
Accepted
14 May 2021
First published
15 May 2021

Chem. Commun., 2021, Advance Article
Article type
Communication

Nongenetic control of receptor signaling dynamics using a DNA-based optochemical tool

R. Ueki, S. Hayashi, M. Tsunoda, M. Akiyama, H. Liu, T. Ueno, Y. Urano and S. Sando, Chem. Commun., 2021, Advance Article , DOI: 10.1039/D1CC01968F

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