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Bio-orthogonal chemistry enables solid phase synthesis and HPLC and gel-free purification of long RNA oligonucleotides

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Abstract

Solid phase synthesis of RNA oligonucleotides which are over 100-nt in length remains challenging due to the complexity of purification of the target strand from failure sequences. This work describes a non-chromatographic strategy that will enable routine solid phase synthesis of long RNA strands.

Graphical abstract: Bio-orthogonal chemistry enables solid phase synthesis and HPLC and gel-free purification of long RNA oligonucleotides

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Article information


Submitted
27 Jan 2021
Accepted
19 Mar 2021
First published
23 Mar 2021

Chem. Commun., 2021, Advance Article
Article type
Communication

Bio-orthogonal chemistry enables solid phase synthesis and HPLC and gel-free purification of long RNA oligonucleotides

M. He, X. Wu, S. Mao, P. Haruehanroengra, I. Khan, J. Sheng and M. Royzen, Chem. Commun., 2021, Advance Article , DOI: 10.1039/D1CC00096A

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