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Rh(iii)-Catalyzed switchable C–H functionalization of 2-(1H-pyrazol-1-yl)pyridine with internal alkynes

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Abstract

We described a Rh(III)-catalyzed and solvent-controlled C–H bond functionalization of 2-(1H-pyrazol-1-yl)pyridine with internal alkynes, which provided a straightforward way for the divergent synthesis of either C–H alkenylation products or indazole products in moderate to good yields. Control experiments were conducted, and a mechanism involving the rollover intermediates was proposed.

Graphical abstract: Rh(iii)-Catalyzed switchable C–H functionalization of 2-(1H-pyrazol-1-yl)pyridine with internal alkynes

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Submitted
24 Feb 2020
Accepted
24 Mar 2020
First published
25 Mar 2020

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Rh(III)-Catalyzed switchable C–H functionalization of 2-(1H-pyrazol-1-yl)pyridine with internal alkynes

S. Wu, Z. Wang, D. Ma, C. Chen and B. Zhu, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/D0QO00248H

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