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Issue 2, 2020
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Sublimation thermodynamics of nucleobases derived from fast scanning calorimetry

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Abstract

The five fundamental units of the genetic code: uracil (U), thymine (T), cytosine (C), adenine (A) and guanine (G) are known for extremely low vapor pressure and low thermal stability at elevated temperatures. Therefore, application of conventional techniques for the determination of sublimation enthalpies and vapor pressures fails to provide accurate results. Recently, a Fast Scanning Calorimetry method (FSC) for vapor pressure determination was developed for investigation of extremely low volatile, as well as for thermally unstable molecular and ionic molecules. This success has encouraged application of the FSC method for determination of vapor pressures and sublimation enthalpies of the five nucleobases, where available literature data are in disarray. The thermodynamic data of the nucleobases available in the literature were collected, evaluated, and combined with our experimental results to reconcile available experimental data. The set of evaluated thermochemical data on the five nucleobases was recommended as the benchmark properties for these thermally labile compounds.

Graphical abstract: Sublimation thermodynamics of nucleobases derived from fast scanning calorimetry

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Supplementary files

Article information


Submitted
27 Aug 2019
Accepted
09 Dec 2019
First published
10 Dec 2019

Phys. Chem. Chem. Phys., 2020,22, 838-853
Article type
Paper

Sublimation thermodynamics of nucleobases derived from fast scanning calorimetry

A. Abdelaziz, D. H. Zaitsau, A. V. Buzyurov, S. P. Verevkin and C. Schick, Phys. Chem. Chem. Phys., 2020, 22, 838
DOI: 10.1039/C9CP04761A

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