(Hexafluoroacetylacetonato)copper(I)–cycloalkyne complexes as protected cycloalkynes

Naoaki Makio; Yuki Sakata; Tomoko Kuribara; Keisuke Adachi; Yasutomo Hatakeyama; Tomohiro Meguro; Kazunobu Igawa; Katsuhiko Tomooka; Takamitsu Hosoya; Suguru Yoshida

doi:10.1039/D0CC05182A

(Hexafluoroacetylacetonato)copper(i)–cycloalkyne complexes as protected cycloalkynes†

Naoaki Makio,^a Yuki Sakata,^a Tomoko Kuribara,^a Keisuke Adachi,^a Yasutomo Hatakeyama,^a Tomohiro Meguro,^a Kazunobu Igawa,

^b Katsuhiko Tomooka,

^b Takamitsu Hosoya

^a and Suguru Yoshida

*^a

Author affiliations

* Corresponding authors

^a Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan
E-mail: s-yoshida.cb@tmd.ac.jp

^b Institute for Materials Chemistry and Engineering, Kyushu University, 6-1 Kasuga-koen, Kasuga, Fukuoka 816-8580, Japan

Abstract

A protection method for cycloalkynes by the formation of (hexafluoroacetylacetonato)copper(I)–cycloalkyne complexes is disclosed. Various complexes having functional groups were efficiently prepared, which are easily purified by silica-gel column chromatography. Selective click reactions were realized through the complexation of cycloalkynes with copper.

Chemical Communications

(Hexafluoroacetylacetonato)copper(i)–cycloalkyne complexes as protected cycloalkynes†

Abstract

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