Issue 82, 2020
From the journal:

Chemical Communications

Enhanced nuclear accumulation of pyrrole–imidazole polyamides by incorporation of the tri-arginine vector†

Takuya Hidaka, ORCID logo a   Yutaro Tsubono,a   Kaori Hashiya,a   Toshikazu Bando,a   Ganesh N. Pandian ORCID logo b  and  Hiroshi Sugiyama ORCID logo *ab  

* Corresponding authors

a Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan

b Institute for Integrated Cell-Material Science (WPI-iCeMS), Kyoto University, Sakyo, Kyoto 606-8501, Japan
E-mail: hs@kuchem.kyoto-u.ac.jp

Abstract

The tri-arginine moiety enhanced nuclear accumulation of a 12-ring pyrrole–imidazole polyamide (PIP) without compromising sequence-selectivity and achieved efficient repression of SOX2-downstream genes and HER2 transcription in live cells. This simple vector expands the application of long PIPs in live cells by overcoming the compound delivery problems associated with them.

Graphical abstract: Enhanced nuclear accumulation of pyrrole–imidazole polyamides by incorporation of the tri-arginine vector

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D0CC05158F
Article type
Communication
Submitted
29 Jul 2020
Accepted
04 Sep 2020
First published
15 Sep 2020

Chem. Commun., 2020,56, 12371-12374

Permissions

Request permissions

Enhanced nuclear accumulation of pyrrole–imidazole polyamides by incorporation of the tri-arginine vector

T. Hidaka, Y. Tsubono, K. Hashiya, T. Bando, G. N. Pandian and H. Sugiyama, Chem. Commun., 2020, 56, 12371 DOI: 10.1039/D0CC05158F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements