A magnetically responsive drug-loaded nanocatalyst with cobalt-involved redox for the enhancement of tumor ferrotherapy

Abstract

Herein, cobalt-involved redox in a magnetically responsive drug-loaded nanocatalyst (PTX/Co-Lips@Fe₃O₄) was used to convert Fe(III) to Fe(II) for enhancing tumor ferrotherapy for the first time. Moreover, this work highlighted an “all in one” strategy: (1) targeting, chemotherapy, and ferrotherapy in one nanomedicine, and (2) a decrease in GSH quantity, increase in the quantity of efficient catalytic ions, and use of a magnetic field, all in one tumor ferrotherapy enhancement approach.