A multipedal DNA walker for amplified detection of tumor exosomes

Peng Miao; Yuguo Tang

doi:10.1039/D0CC01817A

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A multipedal DNA walker for amplified detection of tumor exosomes†

Peng Miao

*^ab and Yuguo Tang^a

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* Corresponding authors

^a CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, P. R. China
E-mail: miaopeng@sibet.ac.cn, pm3084@nyu.edu

^b Department of Chemistry, New York University, New York 10003, USA

Abstract

We have fabricated an ultrasensitive exosome biosensor based on a multipedal DNA walker with a core of target exosomes. Specific recognition is achieved by introducing a CD63 aptamer and facile separation is obtained with magnetic Fe₃O₄@Au nanoparticles. A limit of detection down to 6/μL is obtained with excellent selectivity.

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Article information

DOI: https://doi.org/10.1039/D0CC01817A
Article type: Communication
Submitted: 09 Mar 2020
Accepted: 01 Apr 2020
First published: 01 Apr 2020

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Chem. Commun., 2020,56, 4982-4985

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A multipedal DNA walker for amplified detection of tumor exosomes

P. Miao and Y. Tang, Chem. Commun., 2020, 56, 4982 DOI: 10.1039/D0CC01817A

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Chemical Communications

A multipedal DNA walker for amplified detection of tumor exosomes†

Abstract

Supplementary files

Article information

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A multipedal DNA walker for amplified detection of tumor exosomes

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