Issue 21, 2019
From the journal:

Journal of Materials Chemistry B

A negatively charged Pt(iv) prodrug for electrostatic complexation with polymers to overcome cisplatin resistance†

Xiaoxu Kang,‡ab   Yingjie Yu,‡cd   Zhigang Chen,e   Yixin Wu,ab   Dengshuai Wei,b   Yao Zhao, ORCID logo f   Fuyi Wang ORCID logo f  and  Haihua Xiao*bg  

* Corresponding authors

a College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, P. R. China

b Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
E-mail: hhxiao@iccas.ac.cn

c Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, P. R. China

d Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA

e College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, P. R. China

f CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China

g University of Chemistry Chinese Academy of Sciences, Beijing 100190, P. R. China

Abstract

A negatively charged Pt(IV) prodrug with lipid tails can self-assemble into nanoparticles via electrostatic complexation with a positively charged hydrophilic polymer, which exhibit great potential for clinical application.

Graphical abstract: A negatively charged Pt(iv) prodrug for electrostatic complexation with polymers to overcome cisplatin resistance

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Article information

DOI
https://doi.org/10.1039/C9TB00155G
Article type
Communication
Submitted
23 Jan 2019
Accepted
18 Apr 2019
First published
23 Apr 2019

J. Mater. Chem. B, 2019,7, 3346-3350

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A negatively charged Pt(IV) prodrug for electrostatic complexation with polymers to overcome cisplatin resistance

X. Kang, Y. Yu, Z. Chen, Y. Wu, D. Wei, Y. Zhao, F. Wang and H. Xiao, J. Mater. Chem. B, 2019, 7, 3346 DOI: 10.1039/C9TB00155G

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