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Magnetic liposomes for light sensitive drug delivery and combined photothermal-chemotherapy of tumor

Abstract

Targeted delivery of anticancer drugs for improving therapeutic efficacy and reducing side effects has attracted great attention in cancer therapy. In this work, multifunctional magnetic nanoparticles-loaded thermosensitive liposomes (Fe3O4-TSL) have been developed for the near-infrared (NIR) laser triggered release and combined photothermal-chemotherapy of tumor. Doxorubicin (DOX) was encapsulated into the Fe3O4-TSL (DOX-Fe3O4-TSL) via an ammonium sulfate gradient and the encapsulation efficiency was up to 90.9%. Once treated with NIR laser irradiation, significantly improved drug release efficiency was observed in the DOX-Fe3O4-TSL compared to DOX-TSL. After intravenous injection, Fe3O4-TSL tended to enrich in the tumor over time and showed remarkable magnetic resonance imaging (MRI) and photothermal effects. The combined chemo-photothermal therapy study demonstrated that DOX-Fe3O4-TSL could significantly inhibit the tumor growth while causing no significant damage to normal tissues under NIR laser irradiation. These results reveal a great potential of DOX-Fe3O4-TSL for diagnosis and synergistic therapy of tumor.

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Publication details

The article was received on 11 Oct 2018, accepted on 06 Jan 2019 and first published on 14 Jan 2019


Article type: Paper
DOI: 10.1039/C8TB02684J
Citation: J. Mater. Chem. B, 2019, Accepted Manuscript
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    Magnetic liposomes for light sensitive drug delivery and combined photothermal-chemotherapy of tumor

    S. Shen, D. Huang, J. Cao, Y. Chen, X. Zhang, S. Guo, W. Ma, X. Qi, Y. Ge and L. Wu, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C8TB02684J

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