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Issue 68, 2019
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Sulfamic acid promoted one-pot multicomponent reaction: a facile synthesis of 4-oxo-tetrahydroindoles under ball milling conditions

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Abstract

We report an efficient and facile one-pot synthesis of 4-oxo-tetrahydroindoles using sulfamic acid under ball milling conditions. The present protocol for preparation of biologically important 4-oxo-tetrahydroindoles offers several advantages such as mild reaction conditions, improved selectivity and higher isolated yields. Moreover, solvent-free reaction conditions and the use of ball milling make the present protocol environmentally friendly in nature.

Graphical abstract: Sulfamic acid promoted one-pot multicomponent reaction: a facile synthesis of 4-oxo-tetrahydroindoles under ball milling conditions

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Supplementary files

Article information


Submitted
16 Oct 2019
Accepted
19 Nov 2019
First published
03 Dec 2019

This article is Open Access

RSC Adv., 2019,9, 39735-39742
Article type
Paper

Sulfamic acid promoted one-pot multicomponent reaction: a facile synthesis of 4-oxo-tetrahydroindoles under ball milling conditions

T. L. Lambat, A. A. Abdala, S. Mahmood, P. V. Ledade, R. G. Chaudhary and S. Banerjee, RSC Adv., 2019, 9, 39735
DOI: 10.1039/C9RA08478A

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