Issue 68, 2019
From the journal:

RSC Advances

Sulfamic acid promoted one-pot multicomponent reaction: a facile synthesis of 4-oxo-tetrahydroindoles under ball milling conditions†

Trimurti L. Lambat, ORCID logo *a   Ahmed A. Abdala,b   Sami Mahmood, ORCID logo c   Pankaj V. Ledade,d   Ratiram G. Chaudhary ORCID logo e  and  Subhash Banerjee*f  

* Corresponding authors

a Department of Chemistry, Manoharbhai Patel College of Arts, Commerce & Science, Deori, Dist-Gondia 441901, Maharashtra, India
E-mail: lambatges@gmail.com
Tel: +917972047470

b Chemical Engineering Program, Texas A & M University at Qatar, POB 23784, Doha, Qatar

c Department of Physics, The University of Jordan, Amman 11942, Jordan

d Department of Chemistry, Yashwantrao Chawhan Arts, Commerce & Science College, Lakhandur, Bhandara 441803, Maharashtra, India

e Post Graduate Department of Chemistry, S. K. Porwal College of Arts, Commerce & Science, Kamptee-441001, India

f Department of Chemistry, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India
E-mail: ocsb2006@gmail.com
Fax: +917752260148
Tel: +917587401979

Abstract

We report an efficient and facile one-pot synthesis of 4-oxo-tetrahydroindoles using sulfamic acid under ball milling conditions. The present protocol for preparation of biologically important 4-oxo-tetrahydroindoles offers several advantages such as mild reaction conditions, improved selectivity and higher isolated yields. Moreover, solvent-free reaction conditions and the use of ball milling make the present protocol environmentally friendly in nature.

Graphical abstract: Sulfamic acid promoted one-pot multicomponent reaction: a facile synthesis of 4-oxo-tetrahydroindoles under ball milling conditions

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Article information

DOI
https://doi.org/10.1039/C9RA08478A
Article type
Paper
Submitted
16 Oct 2019
Accepted
19 Nov 2019
First published
03 Dec 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 39735-39742

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Sulfamic acid promoted one-pot multicomponent reaction: a facile synthesis of 4-oxo-tetrahydroindoles under ball milling conditions

T. L. Lambat, A. A. Abdala, S. Mahmood, P. V. Ledade, R. G. Chaudhary and S. Banerjee, RSC Adv., 2019, 9, 39735 DOI: 10.1039/C9RA08478A

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