Issue 40, 2019, Issue in Progress
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RSC Advances

Crystal structure of a DNA duplex cross-linked by 6-thioguanine–6-thioguanine disulfides: reversible formation and cleavage catalyzed by Cu(ii) ions and glutathione†

Akira Ono, ORCID logo *a   Takahiro Atsugi,a   Misato Goto,a   Hisao Saneyoshi,a   Takahito Tomori,b   Kohji Seio,b   Takenori Dairakuc  and  Jiro Kondo*d  

* Corresponding authors

a Department of Materials & Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama, 221-866 Kanagawa, Japan
E-mail: akiraono@kanagawa-u.ac.jp

b School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan
E-mail: kseio@bio.titech.ac.jp

c School of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomita-machi, Koriyama, Fukushima 963-861, Japan
E-mail: t-dairaku@pha.ohu-u.ac.jp

d Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo 102-8554, Japan
E-mail: j.kondo@sophia.ac.jp

Abstract

Herein, we determined the crystal structure of a DNA duplex containing consecutive 6-thioguanine–6-thioguanine disulfides. The disulfide bonds were reversibly formed and cleaved in the presence of Cu(II) ions and glutathione. To our knowledge, this is the first reaction in which metal ions efficiently accelerated disulfide bond formation between thio-bases in duplexes.

Graphical abstract: Crystal structure of a DNA duplex cross-linked by 6-thioguanine–6-thioguanine disulfides: reversible formation and cleavage catalyzed by Cu(ii) ions and glutathione

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Article information

DOI
https://doi.org/10.1039/C9RA03515J
Article type
Paper
Submitted
10 May 2019
Accepted
04 Jul 2019
First published
24 Jul 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 22859-22862

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Crystal structure of a DNA duplex cross-linked by 6-thioguanine–6-thioguanine disulfides: reversible formation and cleavage catalyzed by Cu(II) ions and glutathione

A. Ono, T. Atsugi, M. Goto, H. Saneyoshi, T. Tomori, K. Seio, T. Dairaku and J. Kondo, RSC Adv., 2019, 9, 22859 DOI: 10.1039/C9RA03515J

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