Issue 40, 2019, Issue in Progress

Crystal structure of a DNA duplex cross-linked by 6-thioguanine–6-thioguanine disulfides: reversible formation and cleavage catalyzed by Cu(ii) ions and glutathione

Abstract

Herein, we determined the crystal structure of a DNA duplex containing consecutive 6-thioguanine–6-thioguanine disulfides. The disulfide bonds were reversibly formed and cleaved in the presence of Cu(II) ions and glutathione. To our knowledge, this is the first reaction in which metal ions efficiently accelerated disulfide bond formation between thio-bases in duplexes.

Graphical abstract: Crystal structure of a DNA duplex cross-linked by 6-thioguanine–6-thioguanine disulfides: reversible formation and cleavage catalyzed by Cu(ii) ions and glutathione

Supplementary files

Article information

Article type
Paper
Submitted
10 May 2019
Accepted
04 Jul 2019
First published
24 Jul 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 22859-22862

Crystal structure of a DNA duplex cross-linked by 6-thioguanine–6-thioguanine disulfides: reversible formation and cleavage catalyzed by Cu(II) ions and glutathione

A. Ono, T. Atsugi, M. Goto, H. Saneyoshi, T. Tomori, K. Seio, T. Dairaku and J. Kondo, RSC Adv., 2019, 9, 22859 DOI: 10.1039/C9RA03515J

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