Issue 4, 2019
From the journal:

RSC Advances

Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran†

Chuan-Tao Zhang,a   Rui Zhu,a   Zheng Wang,a   Bing Ma,b   Adrian Zajac,c   Marcin Smiglak, ORCID logo c   Chun-Nian Xia,d   Steven L. Castle ORCID logo *e  and  Wen-Long Wang ORCID logo *a  

* Corresponding authors

a School of Pharmaceutical Science, Jiangnan University, Wuxi, China
E-mail: wwenlong2011@163.com

b Hybrid-Chem Technologies, Shanghai, China

c Poznan Science and Technology Park, Adam Mickiewicz University Foundation, ul Rubiez 46, Poznan, Poland

d Zhejiang University of Technology, Hangzhou, China

e Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA
E-mail: scastle@chem.byu.edu

Abstract

An efficient continuous flow sequential synthesis of diaryl ketones was achieved by coupling of aryl Grignard reagents with acyl chlorides in the bio-derived “green” solvent 2-methyltetrahydrofuran (2-MeTHF) under mild reaction conditions (ambient temperature, 1 hour), allowing a safe and on-demand generation of 2-(3-benzoylphenyl)propionitrile with a productivity of 3.16 g hour−1.

Graphical abstract: Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran

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Article information

DOI
https://doi.org/10.1039/C8RA07447J
Article type
Paper
Submitted
06 Sep 2018
Accepted
10 Jan 2019
First published
17 Jan 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 2199-2204

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Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran

C. Zhang, R. Zhu, Z. Wang, B. Ma, A. Zajac, M. Smiglak, C. Xia, Steven L. Castle and W. Wang, RSC Adv., 2019, 9, 2199 DOI: 10.1039/C8RA07447J

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