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Visible-light-induced radical hydrodifluoromethylation of alkenes

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Abstract

Described here is the radical-mediated hydrodifluoromethylation of alkenes that occurs under transition-metal-free conditions by using the phosphonium salt [Ph3P+CF2H]Br under the irradiation of 26 W household compact fluorescent light. The reaction lends itself to a convenient protocol for the installation of a C–CF2H bond while maintaining good functional group tolerance.

Graphical abstract: Visible-light-induced radical hydrodifluoromethylation of alkenes

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Publication details

The article was received on 21 Jul 2019, accepted on 04 Sep 2019 and first published on 05 Sep 2019


Article type: Research Article
DOI: 10.1039/C9QO00919A
Org. Chem. Front., 2019, Advance Article

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    Visible-light-induced radical hydrodifluoromethylation of alkenes

    J. Yu, J. Lin, Y. Cao and J. Xiao, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO00919A

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