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DMF/NaOH/H2O: a metal-free system for efficient and chemoselective reduction of α-ketoamides

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Abstract

We have developed a transition metal free method for efficient and chemoselective reduction of C[double bond, length as m-dash]O bonds using DMF as a hydrogen source and solvent. α-Ketoamides bearing various functional groups are smoothly reduced to α-hydroxyamides in high yields with the present DMF/NaOH/H2O reduction system.

Graphical abstract: DMF/NaOH/H2O: a metal-free system for efficient and chemoselective reduction of α-ketoamides

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Publication details

The article was received on 02 Jul 2019, accepted on 03 Sep 2019 and first published on 04 Sep 2019


Article type: Research Article
DOI: 10.1039/C9QO00842J
Org. Chem. Front., 2019, Advance Article

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    DMF/NaOH/H2O: a metal-free system for efficient and chemoselective reduction of α-ketoamides

    R. Ye, F. Hao, G. Liu, Q. Zuo, L. Deng, Z. Jin and J. Wu, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO00842J

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