Ring-opening C(sp3)-C coupling of cyclobutanone oxime esters for the preparation of cyanoalkyl containing heterocycles enabled by photocatalysis
Here we report a ring-opening C(sp3 )-C coupling of cyclobutanone oxime esters for the preparation of cyanoalkyl containing heterocycles under visible-light or sunlight irradiation. The reaction protocol is operationally simple and proceeds at room temperature without extra additives, allowing access a variety of functionalized alkylnitriles in moderate to excellent yields. This transformation shows wide functional group compatibility and can be easily scaled up. Mechanism study discloses that cyanoalkyl radical involved in the present reaction.