Jump to main content
Jump to site search


Ring-opening C(sp3)-C coupling of cyclobutanone oxime esters for the preparation of cyanoalkyl containing heterocycles enabled by photocatalysis

Abstract

Here we report a ring-opening C(sp3 )-C coupling of cyclobutanone oxime esters for the preparation of cyanoalkyl containing heterocycles under visible-light or sunlight irradiation. The reaction protocol is operationally simple and proceeds at room temperature without extra additives, allowing access a variety of functionalized alkylnitriles in moderate to excellent yields. This transformation shows wide functional group compatibility and can be easily scaled up. Mechanism study discloses that cyanoalkyl radical involved in the present reaction.

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 May 2019, accepted on 06 Jun 2019 and first published on 10 Jun 2019


Article type: Research Article
DOI: 10.1039/C9QO00625G
Org. Chem. Front., 2019, Accepted Manuscript

  •   Request permissions

    Ring-opening C(sp3)-C coupling of cyclobutanone oxime esters for the preparation of cyanoalkyl containing heterocycles enabled by photocatalysis

    W. Zhang, Y. Pan, C. Yang, X. Li and B. Wang, Org. Chem. Front., 2019, Accepted Manuscript , DOI: 10.1039/C9QO00625G

Search articles by author

Spotlight

Advertisements