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Issue 11, 2019
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[Ag(bpy)(PPhtBu2)(OCF3)]: a stable nucleophilic reagent for chemoselective and stereospecific trifluoromethoxylation of secondary alkyl nosylates

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Abstract

The development of a thermally stable and light-insensitive nucleophilic trifluoromethoxylative reagent [Ag(bpy)(PPhtBu2)(OCF3)] 2, which was synthesized in high yields via a three-step one-pot process from easily available trifluoromethyl triflate (TFMT) and AgF at room temperature, is described. The high reactivity of reagent 2 was demonstrated by its high yielding chemoselective and stereospecific SN2-type trifluoromethoxylation with secondary alkyl nosylates.

Graphical abstract: [Ag(bpy)(PPhtBu2)(OCF3)]: a stable nucleophilic reagent for chemoselective and stereospecific trifluoromethoxylation of secondary alkyl nosylates

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Publication details

The article was received on 22 Feb 2019, accepted on 03 Apr 2019 and first published on 11 Apr 2019


Article type: Research Article
DOI: 10.1039/C9QO00278B
Org. Chem. Front., 2019,6, 1801-1806

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    [Ag(bpy)(PPhtBu2)(OCF3)]: a stable nucleophilic reagent for chemoselective and stereospecific trifluoromethoxylation of secondary alkyl nosylates

    D. Chen, L. Lu and Q. Shen, Org. Chem. Front., 2019, 6, 1801
    DOI: 10.1039/C9QO00278B

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