Iodine-promoted one pot reaction of pyridin-2-amine with arylmethyl ketone and selenosulfonate: synthesis of 3-(alkylselanyl)-2-arylimidazo[1,2-a]pyridine under transition-metal free conditions

Abstract

A new efficient approach for the I₂ promoted selenium functionalization of in situ generated imidazoheterocycles from 2-bromoacetophenone and 2-aminopyridine utilizing aliphatic selenosulfonate as the selenium source under transition metal-free conditions is developed. The reaction features are good yields, being easy to perform, and applicability to versatile imidazoheterocycles via C–N bond and C–Se bond formation in one pot.