Issue 26, 2019

Iridium-catalyzed intramolecular enantioselective allylation of quinazolin-4(3H)-one derivatives

Abstract

An efficient iridium-catalyzed intramolecular enantioselective allylation of quinazolin-4(3H)-one derivatives has been developed, and the corresponding products were obtained with high reactivity and high to excellent enantioselectivity with tolerance of some functional groups, in which our developed chiral cyclic phosphoramidite ligands greatly promoted the iridium-catalyzed reactivity and enantioselectivity.

Graphical abstract: Iridium-catalyzed intramolecular enantioselective allylation of quinazolin-4(3H)-one derivatives

Supplementary files

Article information

Article type
Paper
Submitted
08 May 2019
Accepted
17 Jun 2019
First published
17 Jun 2019

Org. Biomol. Chem., 2019,17, 6461-6464

Iridium-catalyzed intramolecular enantioselective allylation of quinazolin-4(3H)-one derivatives

F. Peng, H. Tian, P. Zhang, H. Yang and H. Fu, Org. Biomol. Chem., 2019, 17, 6461 DOI: 10.1039/C9OB01057B

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