Issue 17, 2019
From the journal:

Nanoscale

A spherical nucleic acid-based two-photon nanoprobe for RNase H activity assay in living cells and tissues†

Ningning Wang, ORCID logo a   Liran Song,a   Hang Xing,a   Ke Zhang,ac   Ronghua Yang ORCID logo b  and  Jishan Li ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Institute of Chemical Biology and Nanomedicine, Hunan University, Changsha, China
E-mail: jishanli@hnu.edu.cn
Fax: +86-731-88821848

b School of Chemistry and Biological Engineering, Changsha University of Science and Technology, Changsha 410114, China

c Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Ave, Boston, Massachusetts 02115, USA

Abstract

We report here a two-photon nanoprobe for the detection of RNase H activity in living cells and ex vivo tissues by combining a two-photon dye with a spherical nucleic acid (SNA) featuring a DNA/RNA duplex corona and a gold nanoparticle core.

Graphical abstract: A spherical nucleic acid-based two-photon nanoprobe for RNase H activity assay in living cells and tissues

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Article information

DOI
https://doi.org/10.1039/C9NR00880B
Article type
Communication
Submitted
28 Jan 2019
Accepted
04 Apr 2019
First published
08 Apr 2019

Nanoscale, 2019,11, 8133-8137

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A spherical nucleic acid-based two-photon nanoprobe for RNase H activity assay in living cells and tissues

N. Wang, L. Song, H. Xing, K. Zhang, R. Yang and J. Li, Nanoscale, 2019, 11, 8133 DOI: 10.1039/C9NR00880B

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