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Issue 40, 2019
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Environmentally benign nucleophilic substitution reaction of arylalkyl halides in water using CTAB as the inverse phase transfer catalyst

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Abstract

An environmentally benign, practically scalable and highly selective C-arylalkylation of active methylene compounds is developed using CTAB as the inverse phase transfer catalyst in water. The methodology developed is elaborated into the one-pot synthesis of quinoline derivatives and also applicable to the regioselective N-aralkyl of 2-pyridones.

Graphical abstract: Environmentally benign nucleophilic substitution reaction of arylalkyl halides in water using CTAB as the inverse phase transfer catalyst

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Article information


Submitted
30 Jul 2019
Accepted
11 Sep 2019
First published
19 Sep 2019

New J. Chem., 2019,43, 16041-16045
Article type
Paper

Environmentally benign nucleophilic substitution reaction of arylalkyl halides in water using CTAB as the inverse phase transfer catalyst

A. K. Godha, J. Thiruvengadam, V. Abhilash, P. Balgi, A. V. Narayanareddy, K. Vignesh, A. V. Gadakh, A. M. Sathiyanarayanan and S. Ganesh, New J. Chem., 2019, 43, 16041
DOI: 10.1039/C9NJ03941D

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