Chiral co-selector induced chirality switching in the enantioseparation of ofloxacin by forming a co-crystal

Abstract

A novel strategy for chirality switching in crystallization-based enantioseparation was developed through cocrystallization using chiral co-selectors. The reversal of chiral selectivity for separation of ofloxacin could be achieved by the combination of two specific tartaric acid derivatives, due to the spatial effects between the molecules.