Saccharin (SacH) reacts with the dialkylcyanamides NCNR2 (R2 = Me2, Et2, C4H8, C5H10, and C4H8O) to grant the guanidinated saccharin derivatives Sac-C(C6H4–2-SO3−H)![[double bond, length as m-dash]](https://www.rsc.org/images/entities/char_e001.gif)
NC+(NH2)NR2 (65–91%) generated via three-component integration; this type of reactivity has never been observed before for saccharin or any of the nitrile substrates.
A. Yu. Dubovtsev, D. M. Ivanov, U. Dabranskaya, N. A. Bokach and V. Yu. Kukushkin, New J. Chem., 2019, 43, 10685 DOI: 10.1039/C9NJ02656H
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