First access to a mycolic acid-based bioorthogonal reporter for the study of the mycomembrane and mycoloyltransferases in Corynebacteria†
Marie
Buchotte, 
a
Gilles
Doisneau,
a
Dominique
Urban,
a
Jean-Marie
Beau,
ab
Nicolas
Bayan,
c
Boris
Vauzeilles,
ab
Dominique
Guianvarc’h
*a
and
Yann
Bourdreux
*a
a
Gilles
Doisneau,
a
Dominique
Urban,
a
Jean-Marie
Beau,
ab
Nicolas
Bayan,
c
Boris
Vauzeilles,
ab
Dominique
Guianvarc’h
*a
and
Yann
Bourdreux
*a
Abstract
In this study, we report the first synthesis of an alkyne-based trehalose monomycolate probe containing a β-hydroxylated fatty acid and an α-branched chain similar to those of the natural mycolic acid. We demonstrate its utility for the labeling of the mycomembrane of Corynebacteria as well as for the study of mycoloyltransferases.
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