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A one-pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions

Abstract

Herein, we report a new prebiotically plausible pathway towards a pyrimidine nucleobase in continuous manner. The route involves simultaneous methylation and carbamoylation of cyanoacetylene-derived α,β-unsaturated thioamide with N-methyl-N-nitrosourea (MNU) in aqueous media. This provides S-methylpyrimidinone in one-pot, which can be converted into a variety of 4-substituted pyrimidine nucleobases including cytosine and uracil.

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Publication details

The article was received on 27 Nov 2018, accepted on 07 Jan 2019 and first published on 07 Jan 2019


Article type: Communication
DOI: 10.1039/C8CC09435G
Citation: Chem. Commun., 2019, Accepted Manuscript
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    A one-pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions

    H. Okamura, S. Becker, N. Tiede, S. Wiedemann, J. Feldmann and T. Carell, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C8CC09435G

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