Directing GDNF-mediated neuronal signaling with proactively programmable cell-surface saccharide-free glycosaminoglycan mimetics

Shuting Cai; Daniel H. Lukamto; Jerry K. C. Toh; Roland G. Huber; Peter J. Bond; Joo-Eun Jee; Teck Chuan Lim; Pei Liu; Liwei Chen; Qianqian Vicky Qu; Su Seong Lee; Song-Gil Lee

doi:10.1039/C8CC09253B

Directing GDNF-mediated neuronal signaling with proactively programmable cell-surface saccharide-free glycosaminoglycan mimetics†

Shuting Cai,‡^a Daniel H. Lukamto,‡^a Jerry K. C. Toh,§^a Roland G. Huber,

^b Peter J. Bond,

^bc Joo-Eun Jee,^a Teck Chuan Lim,

^a Pei Liu,^a Liwei Chen,^a Qianqian Vicky Qu,^a Su Seong Lee

^a and Song-Gil Lee

*^a

Author affiliations

* Corresponding authors

^a Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore
E-mail: sglee@ibn.a-star.edu.sg

^b Bioinformatics Institute, 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Singapore

^c Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore

Abstract

A significant barrier to harnessing the power of cell-surface glycosaminoglycans (GAGs) to modulate glial cell-line-derived neurotrophic factor (GDNF) signaling is the difficulty in accessing key GAG structures involved. Here, we report tailored GDNF signaling using synthetic polyproline-based GAG mimetics (PGMs). PGMs deliver the much needed proactive programmability for GDNF recognition and effectively modulate GDNF-mediated neuronal processes in a cellular context.

Chemical Communications

Directing GDNF-mediated neuronal signaling with proactively programmable cell-surface saccharide-free glycosaminoglycan mimetics†

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Directing GDNF-mediated neuronal signaling with proactively programmable cell-surface saccharide-free glycosaminoglycan mimetics

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