Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs

Marja ter Meer; Ross Dillion; Signe Maria Nielsen; Raoul Walther; Rikke L. Meyer; Willeke F. Daamen; Lambertus P. van den Heuvel; J. Adam van der Vliet; Roger M. L. M. Lomme; Yvonne L. Hoogeveen; Leo J. Schultze Kool; Jeremy E. Schaffer; Alexander N. Zelikin

doi:10.1039/C8CC08737G

Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs†

Marja ter Meer,*^a Ross Dillion,

^b Signe Maria Nielsen,^c Raoul Walther,^d Rikke L. Meyer,^c Willeke F. Daamen,

^e Lambertus P. van den Heuvel,^fg J. Adam van der Vliet,

^h Roger M. L. M. Lomme,^h Yvonne L. Hoogeveen,

^a Leo J. Schultze Kool,^a Jeremy E. Schaffer

*^b and Alexander N. Zelikin

*^cd

Author affiliations

* Corresponding authors

^a Department of Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, The Netherlands
E-mail: Marja.Bulte-terMeer@Radboudumc.nl

^b Fort Wayne Metals Research Products Corp, Research and Development, Fort Wayne, IN, USA
E-mail: jeremy_schaffer@fwmetals.com

^c iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus, Denmark

^d Department of Chemistry, Aarhus University, Aarhus, Denmark
E-mail: zelikin@chem.au.dk

^e Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands

^f Department of Pediatrics/Pediatric Nephrology, Radboud university medical center, Nijmegen, The Netherlands

^g Department of Development and Regeneration/Pediatrics, Catholic University Leuven, Leuven, Belgium

^h Department of Surgery, Radboud university medical center, Nijmegen, The Netherlands

Abstract

Iron-containing metallic implants are shown herein to mediate hydrolysis of glycosidic linkages. Using glucuronide prodrugs for broad-spectrum fluoroquinolone antibacterial agents, we capitalize on this behaviour and perform localized synthesis of antimicrobials which affords a significant zone of inhibition of bacterial growth around the metallic material.

Chemical Communications

Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs†

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