Issue 8, 2019
From the journal:

Chemical Communications

Tumor targeting with DGEA peptide ligands: a new aromatic peptide amphiphile for imaging cancers†

Fu-Kai Zhan,a   Jyun-Cheng Liu,b   Bill Cheng,a   Yen-Chu Liu,a   Tsung-Sheng Lai,a   Hsin-Chieh Lin ORCID logo *a  and  Mei-Yu Yeh ORCID logo *b  

* Corresponding authors

a Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, Taiwan
E-mail: hclin45@nctu.edu.tw

b Department of Chemistry, Chung Yuan Christian University, Taoyuan, Taiwan
E-mail: myyeh@cycu.edu.tw

Abstract

We report a novel fluorescent bioprobe, tetraphenylethylene-Phe-Asp-Gly-Glu-Ala (TPE-FDGEA), and its self-assembly behavior, photophysical properties, and biocompatibility. The hydrogelator TPE-FDGEA exhibited aggregation-induced emission characteristics, which facilitated imaging of PC-3 human prostate cancer cells, thereby demonstrating the utility of such fluorescent probes for specific labeling of target cells in vitro.

Graphical abstract: Tumor targeting with DGEA peptide ligands: a new aromatic peptide amphiphile for imaging cancers

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Article information

DOI
https://doi.org/10.1039/C8CC08679F
Article type
Communication
Submitted
30 Oct 2018
Accepted
31 Dec 2018
First published
02 Jan 2019

Chem. Commun., 2019,55, 1060-1063

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Tumor targeting with DGEA peptide ligands: a new aromatic peptide amphiphile for imaging cancers

F. Zhan, J. Liu, B. Cheng, Y. Liu, T. Lai, H. Lin and M. Yeh, Chem. Commun., 2019, 55, 1060 DOI: 10.1039/C8CC08679F

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