Issue 24, 2018, Issue in Progress

Magnetic surface molecularly imprinted poly(3-aminophenylboronic acid) for selective capture and determination of diethylstilbestrol

Abstract

Diethylstilbestrol (DES) is considered a representative example of an exogenous endocrine disrupting compound (EDC). It can retard development in infants, lead to serious metabolic regulation disorders, and even result in distortion and cancer in the reproductive system. Therefore, achieving rapid and accurate analysis of trace amounts of DES in complex environments is of great importance to human health and for environmental protection. Novel magnetic molecularly imprinted polymers (MIPs) with excellent molecular recognition ability and super water-compatibility were developed for the selective capture of DES in water samples. Fe3O4@SiO2 magnetic nanoparticles (NPs) were synthesized and used as support cores. Molecularly imprinted poly(3-aminophenylboronic acid) (poly(APBA)), synthesized on magnetic cores based on a surface-imprinting strategy, can preferentially bind DES molecules in water samples. The magnetic core–shell MIPs (denoted as Fe3O4@SiO2@APBA/MIPs) exhibited high binding capacity and favorable recognition specificity for DES in water. The adsorption kinetics and experimental isotherm data of DES on magnetic MIPs can be well described by the pseudo-second-order kinetic model and the Langmuir isotherm, respectively. The imprinted nanoparticles were subjected to magnetic solid-phase extraction (MSPE) of DES from water samples. The DES content in the samples was determined by high-performance liquid chromatography (HPLC). The peak area increased linearly with increasing DES concentration over the range 0.08–150 μg L−1, with a detection limit of 0.03 μg L−1. The recoveries for spiked lake water samples were in the range 97.1–103.2%, with relative standard deviation (RSD) of 2.8–4.3% (n = 6).

Graphical abstract: Magnetic surface molecularly imprinted poly(3-aminophenylboronic acid) for selective capture and determination of diethylstilbestrol

Article information

Article type
Paper
Submitted
08 Feb 2018
Accepted
24 Mar 2018
First published
09 Apr 2018
This article is Open Access
Creative Commons BY license

RSC Adv., 2018,8, 13129-13141

Magnetic surface molecularly imprinted poly(3-aminophenylboronic acid) for selective capture and determination of diethylstilbestrol

W. Zhao, T. Kang, L. Lu and S. Cheng, RSC Adv., 2018, 8, 13129 DOI: 10.1039/C8RA01250D

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