Issue 32, 2018

Anti-inflammatory and antioxidant activities of flavonoids from the flowers of Hosta plantaginea

Abstract

Hosta plantaginea was a traditional Chinese medicinal plant used to treat inflammation-related diseases with little scientific validation. Twelve flavonoids, including two new compounds namely plantanones A (1) and B (2), were isolated from the flowers of Hosta plantaginea. Their structures were elucidated by NMR and HRMS as well as comparison with literature data. All of the isolated compounds showed significant inhibitory activities against ovine COX-1 and COX-2 at a concentration of 50 μM, with inhibition ratios from 53.00% to 80.55% for COX-1 and from 52.19% to 66.29% for COX-2. Further detailed testing showed that compounds 1, 2, 4 and 12 inhibited the COX-1 and COX-2 enzymes with IC50 values 12.90–33.37 μM and 38.32–46.16 μM, respectively. Moreover, the antioxidant effects of these isolates against DPPH free radical-scavenging were also evaluated in vitro, and a tight structure-activity relationship was discussed. Our results suggested that the anti-inflammatory and antioxidant activities of H. plantaginea flowers are partly attributed to these flavonoids.

Graphical abstract: Anti-inflammatory and antioxidant activities of flavonoids from the flowers of Hosta plantaginea

Supplementary files

Article information

Article type
Paper
Submitted
15 Jan 2018
Accepted
11 May 2018
First published
17 May 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 18175-18179

Anti-inflammatory and antioxidant activities of flavonoids from the flowers of Hosta plantaginea

J. He, L. Yang, Z. Mu, Y. Zhu, G. Zhong, Z. Liu, Q. Zhou and F. Cheng, RSC Adv., 2018, 8, 18175 DOI: 10.1039/C8RA00443A

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