DDQ-mediated direct C(sp3)–H phosphorylation of xanthene derivatives

Abstract

A convenient and efficient C(sp³)–H phosphorylation has been achieved via the metal-free DDQ-mediated cross-dehydrogenative coupling between diarylphosphine oxides and xanthene derivatives at room temperature. This transformation provides a direct synthetic route to the construction of C(sp³)–P bonds with good functional group compatibility, leading to the formation of alkylphosphonates in up to 96% yield.