Issue 8, 2018

Visible-light-mediated iodine-catalyzed α-hydroxylation of α-methylene ketones under aerobic conditions

Abstract

Visible light, in combination with the molecular iodine catalyst-mediated α-hydroxylation of α-methylene ketones, has been developed. The reaction proceeds smoothly in methanol at room temperature under aerobic conditions and shows exclusive selectivity toward methylene ketones. Mechanistic studies have revealed that the reaction proceeds by a radical pathway. Renewable energy, metal-free catalyst and abundant oxygen source alongside a wide scope and novel selectivity are features that make this strategy practical and eco-friendly.

Graphical abstract: Visible-light-mediated iodine-catalyzed α-hydroxylation of α-methylene ketones under aerobic conditions

Supplementary files

Article information

Article type
Research Article
Submitted
18 Jan 2018
Accepted
22 Feb 2018
First published
23 Feb 2018

Org. Chem. Front., 2018,5, 1325-1329

Visible-light-mediated iodine-catalyzed α-hydroxylation of α-methylene ketones under aerobic conditions

J. Yang, D. Xie, H. Zhou, S. Chen, C. Huo and Z. Li, Org. Chem. Front., 2018, 5, 1325 DOI: 10.1039/C8QO00056E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements