Co(iii)-Catalyzed N-chloroamide-directed C–H activation for 3,4-dihydroisoquinolone synthesis

Abstract

The synthesis of 3,4-dihydroisoquinolone via Co(III)-catalyzed C–H activation has been achieved for the first time. N-Chloroamides as a C–H activation directing synthon react effectively with alkenes at room temperature, enabling the incorporation of diverse reactive functionalities and substitution patterns into the target heterocycles.