We report a modular five step synthetic route to the febrifugines that employs 2-(chloromethyl)allyl-trimethylsilane as a conjunctive reagent for the coupling of the piperidine and quinazolinone groups. We also demonstrate the application of a recent Rh-catalyzed quinazolinone synthesis for the facile generation of febrifugine analogs.
T. M. M. Maiden, N. Mbelesi, P. A. Procopiou, S. Swanson and J. P. A. Harrity, Org. Biomol. Chem., 2018, 16, 4159 DOI: 10.1039/C8OB00935J
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