Issue 6, 2018

The thiolation of pentafluorobenzene with disulfides by C–H, C–F bond activation and C–S bond formation

Abstract

A metal-free thiolation reaction between pentafluorobenzene and disulfides by C–H, C–F bond activation and C–S bond formation is reported. Bisthiolated tetrafluorobenzene derivatives would be prepared in moderate to good yields from pentafluorobenzene and disulfides under mild conditions. A possible mechanism for the reaction was given.

Graphical abstract: The thiolation of pentafluorobenzene with disulfides by C–H, C–F bond activation and C–S bond formation

Supplementary files

Article information

Article type
Paper
Submitted
18 Nov 2017
Accepted
10 Jan 2018
First published
10 Jan 2018

Org. Biomol. Chem., 2018,16, 988-992

The thiolation of pentafluorobenzene with disulfides by C–H, C–F bond activation and C–S bond formation

Z. Liu, K. Ouyang and N. Yang, Org. Biomol. Chem., 2018, 16, 988 DOI: 10.1039/C7OB02836A

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