Jump to main content
Jump to site search

Issue 12, 2018
Previous Article Next Article

A continuous flow approach for the C–H functionalization of 1,2,3-triazoles in γ-valerolactone as a biomass-derived medium

Author affiliations

Abstract

Herein we report an efficient procedure for the C–H functionalization of 1,2,3-triazoles in a continuous flow regime applied to a variety of functionalities and to the inter- or intramolecular versions of the process. The continuous-flow protocol is based on the use of a heterogeneous catalyst (Pd/C), a soluble organic base and GVL as the reaction medium. Flow conditions allow an optimal recovery/reuse and durability of the catalyst, which combined with the simple purification of the products and the recovery of the reaction medium make the proposed protocol operationally simple and very efficient in terms of waste minimization as proven by low metal leaching and a low associated E-factor.

Graphical abstract: A continuous flow approach for the C–H functionalization of 1,2,3-triazoles in γ-valerolactone as a biomass-derived medium

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Apr 2018, accepted on 24 May 2018 and first published on 24 May 2018


Article type: Paper
DOI: 10.1039/C8GC01115J
Citation: Green Chem., 2018,20, 2888-2893
  •   Request permissions

    A continuous flow approach for the C–H functionalization of 1,2,3-triazoles in γ-valerolactone as a biomass-derived medium

    F. Ferlin, L. Luciani, S. Santoro, A. Marrocchi, D. Lanari, A. Bechtoldt, L. Ackermann and L. Vaccaro, Green Chem., 2018, 20, 2888
    DOI: 10.1039/C8GC01115J

Search articles by author

Spotlight

Advertisements