Issue 1, 2018
From the journal:

Green Chemistry

Catalyst- and solvent-free bisphosphinylation of isothiocyanates: a practical method for the synthesis of bisphosphinoylaminomethanes†

Li-Rong Wen, ORCID logo ab   Yong-Xu Sun,a   Jin-Wei Zhang,b   Wei-Si Guo*ab  and  Ming Li ORCID logo *a  

* Corresponding authors

a State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China
E-mail: nick8110@163.com, liming928@qust.edu.cn

b State Key Laboratory for Marine Corrosion and Protection, Luoyang Ship Material Research Institute (LSMRI), Qingdao 266101, P. R. China

Abstract

A general and convenient double addition of phosphine oxides to isothiocyanates is described. It is a practically useful protocol for the construction of bisphosphinoylaminomethanes. The reaction can be carried out smoothly under metal- and solvent-free conditions. It also features a broad substrate scope, simple operation and purification. A possible mechanism involving a tandem double nucleophilic addition/H2S elimination/in situ imine reduction process is proposed.

Graphical abstract: Catalyst- and solvent-free bisphosphinylation of isothiocyanates: a practical method for the synthesis of bisphosphinoylaminomethanes

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Article information

DOI
https://doi.org/10.1039/C7GC03101G
Article type
Communication
Submitted
14 Oct 2017
Accepted
27 Nov 2017
First published
27 Nov 2017

Green Chem., 2018,20, 125-129

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Catalyst- and solvent-free bisphosphinylation of isothiocyanates: a practical method for the synthesis of bisphosphinoylaminomethanes

L. Wen, Y. Sun, J. Zhang, W. Guo and M. Li, Green Chem., 2018, 20, 125 DOI: 10.1039/C7GC03101G

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