Issue 90, 2018

Oxidative coupling of enolates using memory of chirality: an original enantioselective synthesis of quaternary α-amino acid derivatives

Abstract

We describe here the first enantioselective oxidative heterocoupling of enolates. Our strategy relies on the memory of chirality concept and allows the stereocontrolled formation of quaternary centres on α-amino acid derivatives with an enantiomeric excess of up to 94%.

Graphical abstract: Oxidative coupling of enolates using memory of chirality: an original enantioselective synthesis of quaternary α-amino acid derivatives

Supplementary files

Article information

Article type
Communication
Submitted
23 Aug 2018
Accepted
18 Oct 2018
First published
18 Oct 2018

Chem. Commun., 2018,54, 12742-12745

Oxidative coupling of enolates using memory of chirality: an original enantioselective synthesis of quaternary α-amino acid derivatives

A. Mambrini, D. Gori, R. Guillot, C. Kouklovsky and V. Alezra, Chem. Commun., 2018, 54, 12742 DOI: 10.1039/C8CC06864J

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