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Issue 79, 2018
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A facile route to 1H- and 2H-indazoles from readily accessible acyl hydrazides by exploiting a novel aryne-based molecular rearrangement

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Abstract

Herein we report the transformation of readily synthesised acyl hydrazides into 2-hydrazobenzophenones via a novel molecular rearrangement pathway using aryne chemistry. The developed reaction protocol is performed under relatively mild conditions and is tolerant of a wide variety of functional groups, and the 2-hydrazobenzophenone products provide access to both 1H- and 2H-indazoles from a single intermediate.

Graphical abstract: A facile route to 1H- and 2H-indazoles from readily accessible acyl hydrazides by exploiting a novel aryne-based molecular rearrangement

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Supplementary files

Article information


Submitted
11 Aug 2018
Accepted
11 Sep 2018
First published
11 Sep 2018

This article is Open Access

Chem. Commun., 2018,54, 11180-11183
Article type
Communication

A facile route to 1H- and 2H-indazoles from readily accessible acyl hydrazides by exploiting a novel aryne-based molecular rearrangement

A. Shamsabadi and V. Chudasama, Chem. Commun., 2018, 54, 11180
DOI: 10.1039/C8CC06556J

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