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Issue 66, 2018
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Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses

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Abstract

We present a chemical methylome analysis platform to evaluate the inhibitory activity of small molecules towards poorly characterized protein methyltransferases (PMTs), facsilitating to identify syn-HyPA-ETP-2 as a non-histone arginine methyltransferase inhibitor.

Graphical abstract: Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses

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Supplementary files

Article information


Submitted
16 May 2018
Accepted
23 Jul 2018
First published
31 Jul 2018

Chem. Commun., 2018,54, 9202-9205
Article type
Communication

Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses

Y. Sohtome, T. Shimazu, J. Barjau, S. Fujishiro, M. Akakabe, N. Terayama, K. Dodo, A. Ito, M. Yoshida, Y. Shinkai and M. Sodeoka, Chem. Commun., 2018, 54, 9202
DOI: 10.1039/C8CC03907K

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