Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein–Ru(carbene) adduct†
Matthew P.
Sullivan, 
ab
Michél K.
Nieuwoudt,
ac
Nelson Y. S.
Lam,
a
Dianna
Truong,
a
David C.
Goldstone
*b
and
Christian G.
Hartinger
*a
ab
Michél K.
Nieuwoudt,
ac
Nelson Y. S.
Lam,
a
Dianna
Truong,
a
David C.
Goldstone
*b
and
Christian G.
Hartinger
*a
Abstract
The first X-ray structures of adducts formed between a RuII(N-heterocyclic carbene)(η6-p-cymene) compound and a protein are reported. Coordination to the protein induced the cleavage of the cymene ligand and EPR spectroscopy demonstrated the oxidation of the Ru centre.
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