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Issue 15, 2017
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Crystal structure dependent in vitro antioxidant activity of biocompatible calcium gallate MOFs

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Abstract

Two novel 3-D coordination polymers, denoted MIL-155 and MIL-156 (MIL stands for Materials Institute Lavoisier), built up from calcium and the naturally occurring gallic acid (H4gal), have been hydrothermally synthesized and their crystal structures were determined by single-crystal X-ray diffraction. These solids are based on different inorganic subunits: infinite chains of edge-sharing dimers of CaO7 polyhedra linked through partially deprotonated gallate ligands (H2gal2−) for MIL-155 or [Ca2(H2O)(H2gal)2]·2H2O, and ribbon-like inorganic subunits containing both eight-fold or six-fold coordinated CaII ions linked through fully deprotonated gallate ligands (gal4−) for MIL-156 or [Ca3K2(H2O)2(gal)2nH2O (n ∼ 5). Both solids contain small channels filled with water molecules, with, however no accessible porosity towards N2 at 77 K. MIL-155 and MIL-156 were proven to be biocompatible, as evidenced by in vitro assays (viability and cell proliferation/death balance). While the high chemical stability of MIL-156 makes it almost bioinert, the progressive degradation of MIL-155 leads to an important protective antioxidant effect, associated with the release of the bioactive gallate ligand.

Graphical abstract: Crystal structure dependent in vitro antioxidant activity of biocompatible calcium gallate MOFs

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Publication details

The article was received on 29 Nov 2016, accepted on 14 Mar 2017 and first published on 30 Mar 2017


Article type: Paper
DOI: 10.1039/C6TB03101C
Citation: J. Mater. Chem. B, 2017,5, 2813-2822
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    Crystal structure dependent in vitro antioxidant activity of biocompatible calcium gallate MOFs

    T. Hidalgo, L. Cooper, M. Gorman, T. Lozano-Fernández, R. Simón-Vázquez, G. Mouchaham, J. Marrot, N. Guillou, C. Serre, P. Fertey, Á. González-Fernández, T. Devic and P. Horcajada, J. Mater. Chem. B, 2017, 5, 2813
    DOI: 10.1039/C6TB03101C

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